State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
Curr Drug Targets. 2011 Jul 1;12(8):1131-50. doi: 10.2174/138945011795906642.
Nanotechnology provides researchers with new tools for cancer treatment. Biodegradable polymeric nanoparticles, as an advanced drug delivery system, have promising applications in cancer treatment. Poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers are biodegradable and amphiphilic, and show potential application in drug delivery. In recent years, PCL/PEG copolymeric nanoparticles, as a potential nanoplatform for anticancer agent delivery, received increasing attention. This paper reviews PCL/PEG copolymer nanoparticles for anticancer agent delivery, including overcoming water insolubility of hydrophobic drug, targeting chemotherapeutic drug to tumor, and delivering genes, vaccines, and diagnostic agents.
纳米技术为癌症治疗研究人员提供了新的工具。可生物降解的聚合物纳米粒子作为一种先进的药物传递系统，在癌症治疗中有广阔的应用前景。聚（ε-己内酯）/聚乙二醇（PCL/PEG）共聚物可生物降解且具有两亲性，在药物传递方面有很大的应用潜力。近年来，作为抗癌药物传递的潜在纳米平台，PCL/PEG 共聚物纳米粒子受到了越来越多的关注。本文综述了 PCL/PEG 共聚物纳米粒子在抗癌药物传递中的应用，包括克服疏水性药物的水溶性问题、将化疗药物靶向递送到肿瘤部位，以及递送达基因、疫苗和诊断剂等。
