Center for Family and Community Medicine, Karolinska Institutet, Stockholm, Sweden.
Aliment Pharmacol Ther. 2011 Jun;33(11):1215-24. doi: 10.1111/j.1365-2036.2011.04640.x. Epub 2011 Mar 28.
Data on the impact of functional dyspepsia on health-related quality of life in the general adult population are scarce.
To explore the impact of functional dyspepsia applying the Rome III definition on health-related quality of life in the general population.
A random sample of an adult Swedish population (n=1001, The Kalixanda study) was invited to undergo an oesophagogastroduodenoscopy. An extended abdominal symptom questionnaire and Short Form-36 (SF-36) questionnaire, which includes eight domains measuring physical, mental and social aspects of quality of life, were completed at the clinic visit just before oesophagogastroduodenoscopy.
Two hundred and two (20%) individuals reported uninvestigated dyspepsia (UID), 157 (16%) functional dyspepsia (FD), 52 (5%) epigastric pain syndrome (EPS) and 122 (12%) postprandial distress syndrome (PDS). UID, FD and PDS had a clinically meaningful (a ≥ 5 point) and statistically significant impact (P<0.05) on health-related quality of life in all SF-36 domains except for Role Emotional. EPS had a significant impact on Bodily Pain and Vitality. Overlap of FD with irritable bowel syndrome (IBS) had a significant impact on Bodily Pain (P=0.002) and General Health (P=0.02) while FD overlap with gastro-oesophageal reflux symptoms (GERS) had a significant impact on Bodily Pain (P=0.02) compared with FD without any overlap with IBS or GERS.
Functional dyspepsia impacts all main domains describing physical, mental and social aspects of health-related quality of life in the general population. Overlap of functional dyspepsia with irritable bowel syndrome or gastro-oesophageal reflux symptoms impacts the domain related to bodily pain.
关于功能性消化不良对一般成年人群健康相关生活质量影响的数据较为匮乏。
探讨应用罗马 III 标准诊断的功能性消化不良对一般人群健康相关生活质量的影响。
一项瑞典成年人的随机抽样人群（n=1001，Kalixanda 研究）受邀接受上消化道内镜检查。在消化内镜检查前的临床就诊时，完成了扩展腹部症状问卷和健康调查简表 36（Short Form-36，SF-36）问卷，SF-36 问卷包括 8 个领域，用于测量生活质量的身体、心理和社会方面。
202 例（20%）个体报告了未经调查的消化不良（uninvestigated dyspepsia，UID），157 例（16%）功能性消化不良（functional dyspepsia，FD），52 例（5%）上腹痛综合征（epigastric pain syndrome，EPS）和 122 例（12%）餐后不适综合征（postprandial distress syndrome，PDS）。UID、FD 和 PDS 在除了情绪角色以外的所有 SF-36 领域对健康相关生活质量都具有临床显著（a≥5 分）和统计学显著的影响（P<0.05）。EPS 对上腹痛和活力具有显著影响。FD 与肠易激综合征（irritable bowel syndrome，IBS）重叠对身体疼痛（P=0.002）和总体健康（P=0.02）有显著影响，而 FD 与胃食管反流症状（gastro-oesophageal reflux symptoms，GERS）重叠对身体疼痛（P=0.02）有显著影响，与 FD 与 IBS 或 GERS 均无重叠相比。
功能性消化不良对一般人群健康相关生活质量的所有主要描述身体、心理和社会方面的领域都有影响。FD 与 IBS 或 GERS 重叠会影响与身体疼痛相关的领域。
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