Department of Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Oral Oncol. 2011 May;47(5):325-8. doi: 10.1016/j.oraloncology.2011.03.006. Epub 2011 Mar 27.
Odontogenic myxoma (OM) is a benign odontogenic neoplasm that tends to recur due to bone infiltration. This review focuses on the molecular aspects of the OM. The following topics are discussed: clonal nature, matrix metalloproteinases, apoptosis and cell proliferation, genetic alterations, and other markers. Translational studies are necessary to identify the prognostic markers of this lesion, and also, molecular biology studies may help to identify the etiologic factors and to develop more effective and less aggressive approaches, other than surgery, to the treatment of this infiltrating odontogenic tumor.
牙源性黏液瘤（OM）是一种良性牙源性肿瘤，由于骨浸润，其具有易复发的倾向。本综述重点讨论 OM 的分子方面。讨论的主题包括：克隆性质、基质金属蛋白酶、细胞凋亡和增殖、遗传改变和其他标志物。有必要进行转化研究以确定该病变的预后标志物，并且分子生物学研究也可能有助于确定病因因素，并开发比手术更有效和侵袭性更小的方法来治疗这种侵袭性牙源性肿瘤。
