Harvard Institute for Global Health, Cambridge, MA 02138, USA.
AIDS Behav. 2012 Feb;16(2):375-82. doi: 10.1007/s10461-011-9933-y.
Second generation electronic medication adherence monitors provide real-time data on pill bottle opening behavior. Feasibility, validity, and acceptability, however, have not been established. Med-eMonitor is a multi-compartment adherence device with reminder and education capacity that transmits data through a telephone connection. Monthly adherence levels were measured for 52 participants over approximately 3 months using the Med-eMonitor (unadjusted and adjusted for participant confirmed dosing) and unannounced pill counts. HIV RNA was assessed before and after the 3-month period. Acceptability of Med-eMonitor was determined. Over 92% of Med-eMonitor data was transmitted daily. Unannounced pill counts significantly correlated with adjusted Med-eMonitor adherence (r = 0.29, P = 0.04). HIV RNA significantly correlated with unannounced pill counts (r = -0.34, P = 0.02), and trended toward a significant correlation with unadjusted Med-eMonitor adherence (r = -0.26; P = 0.07). Most, but not all, participants liked using the Med-eMonitor. Med-eMonitor allows for real-time adherence monitoring and potentially intervention, which may be critical for prolonging treatment success.
第二代电子药物依从性监测器可提供药瓶开启行为的实时数据。然而，其可行性、有效性和可接受性尚未得到证实。Med-eMonitor 是一种具有提醒和教育功能的多腔依从性装置，通过电话连接传输数据。使用 Med-eMonitor（未调整和根据参与者确认的剂量进行调整）和未宣布的药丸计数，在大约 3 个月的时间内对 52 名参与者的每月依从水平进行了测量。在 3 个月期间前后评估了 HIV RNA。确定了 Med-eMonitor 的可接受性。超过 92%的 Med-eMonitor 数据每天传输。未宣布的药丸计数与调整后的 Med-eMonitor 依从性显著相关（r = 0.29，P = 0.04）。HIV RNA 与未宣布的药丸计数显著相关（r = -0.34，P = 0.02），并且与未调整的 Med-eMonitor 依从性呈显著相关趋势（r = -0.26；P = 0.07）。大多数参与者喜欢使用 Med-eMonitor，但并非全部。Med-eMonitor 允许进行实时依从性监测和潜在干预，这对于延长治疗成功可能至关重要。
