Szebeni Janos
Nanomedicina Kutató és Oktató Központ, Hungary; Semmelweis Egyetem, Bay Zoltán Alkalmazott Kutatási Közalapítvány, Budapest, Hungary.
Neuropsychopharmacol Hung. 2011 Mar;13(1):15-24.
One of the most popular, most intensely expanding borderline of science and technology today is nanomedicine, the utilization of nanotechnology in medicine. The long lists of innovative medicinal and other products, astonishing market and scientometric indicators and the broad scale of promising therapeutic and diagnostic opportunities support the view that nanomedicine heralds the future of medicine. The goals of this review are to provide a comprehensive overview of the field, to compile the nanomedicines and other medical products that are on the market, and to address in more detail the most successful trend, targeted pharmacotherapy. Various nanocarriers (liposomes, micelles, polymer-conjugates, polymerosomes, dendrimers, aptamers and carbon nanotubes) will be presented, along with their targeting ligands, with special emphasis on liposomal doxorubicin (Doxil), the prototype of long-circulating, targeted chemotherapeutic nanomedicine. Nanotechnology holds great promises for the field of neuropsychiatric pharmacotherapy as well, mainly through the introduction of pharmaceutical agents passing the blood-brain barrier. The review presents some of the approaches and examples of these attempts.
当今科学技术中最热门、发展最迅猛的前沿领域之一是纳米医学，即纳米技术在医学中的应用。大量创新的医药及其他产品、惊人的市场和科学计量指标，以及广泛的前景广阔的治疗和诊断机会，都支持了纳米医学预示着医学未来的观点。本综述的目的是全面概述该领域，汇总已上市的纳米药物和其他医疗产品，并更详细地探讨最成功的趋势——靶向药物治疗。将介绍各种纳米载体（脂质体、胶束、聚合物缀合物、聚合物囊泡、树枝状大分子、适配体和碳纳米管）及其靶向配体，特别强调脂质体阿霉素（多美素），这是长效循环、靶向化疗纳米医学的原型。纳米技术在神经精神药物治疗领域也有很大前景，主要是通过引入能够穿过血脑屏障的药剂。本综述介绍了这些尝试的一些方法和实例。
