Wang Zhe, Niu Gang, Chen Xiaoyuan
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering National Institutes of Health, Bldg. 31, 1C22, Bethesda, Maryland, 20892, USA.
Pharm Res. 2014 Jun;31(6):1358-76. doi: 10.1007/s11095-013-1103-7. Epub 2013 Jun 14.
Nanotechnology has continuously contributed to the fast development of diagnostic and therapeutic agents. Theranostic nanomedicine has encompassed the ongoing efforts on concurrent molecular imaging of biomarkers, delivery of therapeutic agents, and monitoring of therapy response. Among these formulations, polymer-based theranostic agents hold great promise for the construction of multifunctional agents for translational medicine. In this article, we reviewed the state-of-the-art polymeric nanoparticles, from preparation to application, as potential theranostic agents for diagnosis and therapy. We summarized several major polymer formulas, including polymeric conjugate complexes, nanospheres, micelles, and dendrimers for integrated molecular imaging and therapeutic applications.
纳米技术不断推动诊断和治疗剂的快速发展。诊疗纳米医学涵盖了对生物标志物的同步分子成像、治疗剂递送以及治疗反应监测等方面的持续努力。在这些制剂中，基于聚合物的诊疗剂在构建用于转化医学的多功能制剂方面具有巨大潜力。在本文中，我们综述了从制备到应用的最先进的聚合物纳米颗粒，作为诊断和治疗的潜在诊疗剂。我们总结了几种主要的聚合物配方，包括用于集成分子成像和治疗应用的聚合物共轭复合物、纳米球、胶束和树枝状大分子。
