Agricultural and Ecological Research Unit, Indian Statistical Institute, 203, BT Road, Calcutta 700 108, India.
J Biosci. 2011 Mar;36(1):27-35. doi: 10.1007/s12038-011-9001-9.
Cleome viscosa L. (Capparidaceae) is well known for its medicinal properties. Lactam nonanoic acid (LNA) [2-amino-9-(4-oxoazetidin-2-yl)-nonanoic acid; C12H22N2O3, mol. wt. 242] has been isolated and purified from the root exudates of Cleome viscosa. The aqueous solution of this pure compound has been tested on bacteria (Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus) and fungi (Aspergillus fumigatus, A. niger and A. tamarii). At a dosage of 500 ppm and above, P. aeruginosa and S. aureus were totally inhibited while E. coli remained unaffected. On the other hand, growth of A. niger and A. tamarii was stimulated while there was no effect on A. fumigatus. This pure compound showed concentration-dependent inhibitory activity on rice, gram and mustard seeds.
Cleome viscosa L.（山蚂蝗科）因其药用特性而广为人知。从Cleome viscosa 的根分泌物中分离和纯化出乳酰胺壬酸（LNA）[2-氨基-9-（4-氧代氮杂环丁烷-2-基）壬酸；C12H22N2O3，分子量 242]。该纯化合物的水溶液已在细菌（大肠杆菌、铜绿假单胞菌和金黄色葡萄球菌）和真菌（烟曲霉、黑曲霉和藤仓赤霉）上进行了测试。在 500ppm 及以上剂量下，铜绿假单胞菌和金黄色葡萄球菌完全被抑制，而大肠杆菌不受影响。另一方面，黑曲霉和藤仓赤霉的生长受到刺激，而对烟曲霉则没有影响。这种纯化合物对水稻、绿豆和芥菜种子表现出浓度依赖性的抑制活性。
