评价Cleome viscosa Linn. 提取物的保肝活性。
Evaluation of hepatoprotective activity of Cleome viscosa Linn. extract.
机构信息
Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar, MP, India.
出版信息
Indian J Pharmacol. 2009 Feb;41(1):36-40. doi: 10.4103/0253-7613.48892.
OBJECTIVES
To evaluate the hepatoprotective activity of ethanolic extract of Cleome viscosa Linn. (Capparidaceae) against carbon tetrachloride (CCI(4)) induced hepatotoxicity in experimental animal models.
MATERIALS AND METHODS
Leaf powder of Cleome viscosa was extracted with ethanol. The hepatoprotective activity of the extract was assessed in CCI(4) induced hepatotoxicity in rats. Various biochemical parameters were estimated and histopathological studies were also performed on rat liver. The hepatoprotective activity was also supported by determining a functional parameter, i.e. thiopental-induced sleep of mice poisoned with CCl(4).
RESULTS
The test material was found effective as hepatoprotective, through in vivo and histopathological studies. The extract was found to be effective in shortening the thiopental induced sleep in mice poisoned with CCl(4). The hepatoprotective effect of ethanolic extract was comparable to that of silymarin, a standard hepatoprotective agent.
CONCLUSION
The results of the present study show that ethanolic extract of Cleome viscosa has significant hepatoprotective activity.
目的
评价白花菜（白花菜科）乙醇提取物对四氯化碳（CCl（4））诱导的实验动物模型肝毒性的保护作用。
材料和方法
用乙醇提取白花菜叶粉。评估提取物在 CCl（4）诱导的大鼠肝毒性中的保护作用。评估了各种生化参数，并对大鼠肝进行了组织病理学研究。通过测定功能性参数，即用 CCl（4）中毒的小鼠的硫喷妥钠诱导的睡眠，也支持了肝保护活性。
结果
通过体内和组织病理学研究发现，受试物具有有效的肝保护作用。提取物可有效缩短用 CCl（4）中毒的小鼠的硫喷妥钠诱导的睡眠。乙醇提取物的肝保护作用与标准肝保护剂水飞蓟素相当。
结论
本研究结果表明，白花菜乙醇提取物具有显著的肝保护活性。
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