白花菜提取物对大鼠的解热潜力评估。（白花菜科）

Evaluation of antipyretic potential of Cleome viscosa Linn. (Capparidaceae) extract in rats.

作者信息

Devi B Parimala, Boominathan R, Mandal Subhash C

机构信息

Division of Pharmacognosy, Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadavpur University, Calcutta 700032, India.

出版信息

J Ethnopharmacol. 2003 Jul;87(1):11-3. doi: 10.1016/s0378-8741(03)00099-0.

DOI:10.1016/s0378-8741(03)00099-0

PMID:12787948

Abstract

The antipyretic activity of a methanol extract of Cleome viscosa Linn. (CVME) was investigated for its potential on normal body temperature and yeast-induced pyrexia in albino rats. The CVME, at doses of 200, 300, and 400mg/kg BW p.o., showed significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose-dependent manner. The effect also extended upto 5h after the drug administration. The anti-pyretic effect of CVME was comparable to that of paracetamol (150mg/kg p.o.), a standard anti-pyretic agent.

摘要

对白花菜（Cleome viscosa Linn.）甲醇提取物（CVME）的解热活性进行了研究，观察其对白化大鼠正常体温及酵母诱导发热的影响。CVME经口服给予剂量为200、300和400mg/kg体重时，能以剂量依赖方式显著降低正常体温及酵母诱发的体温升高。给药后该作用可持续长达5小时。CVME的解热作用与标准解热剂对乙酰氨基酚（口服150mg/kg）相当。