Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen's Medical Centre, Nottingham, UK.
Curr Opin Anaesthesiol. 2011 Jun;24(3):339-48. doi: 10.1097/ACO.0b013e328345865e.
To highlight recent developments in the field of perioperative nutritional support by reviewing clinically pertinent English language articles from October 2008 to December 2010, that examined the effects of malnutrition on surgical outcomes, optimizing metabolic function and nutritional status preoperatively and postoperatively.
Recognition of patients with or at risk of malnutrition remains poor despite the availability of numerous clinical aids and clear evidence of the adverse effects of poor nutritional status on postoperative clinical outcomes. Unfortunately, poor design and significant heterogeneity remain amongst many studies of nutritional interventions in surgical patients. Patients undergoing elective surgery should be managed within a multimodal pathway that includes evidence-based interventions to optimize nutritional status perioperatively. The aforementioned should include screening patients to identify those at high nutritional risk, perioperative immuno-nutrition, minimizing 'metabolic stress' and insulin resistance by preoperative conditioning with carbohydrate-based drinks, glutamine supplementation, minimal access surgery and enhanced recovery protocols. Finally gut-specific nutrients and prokinetics should be utilized to improve enteral feed tolerance thereby permitting early enteral feeding.
An evidence-based multimodal pathway that includes interventions to optimize nutritional status may improve outcomes following elective surgery.
通过回顾 2008 年 10 月至 2010 年 12 月期间的英语临床相关文献,强调围手术期营养支持领域的最新进展,这些文献检查了营养不良对手术结果的影响,优化了代谢功能和术前、术后的营养状况。
尽管有许多临床辅助工具和营养不良对术后临床结果的不良影响的明确证据,但对有或有营养不良风险的患者的认识仍然很差。不幸的是,在许多外科患者的营养干预研究中,设计不佳和显著的异质性仍然存在。择期手术患者应在多模式途径中进行管理,包括循证干预措施,以优化围手术期的营养状况。上述措施应包括筛查高营养风险患者、围手术期免疫营养、通过术前用含碳水化合物的饮料进行预调理、谷氨酰胺补充、微创外科和强化康复方案来最小化“代谢应激”和胰岛素抵抗。最后,应使用肠道特异性营养素和促动力剂来提高肠内喂养耐受性,从而允许早期肠内喂养。
包括优化营养状况干预措施的循证多模式途径可能改善择期手术后的结果。