Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK.
J Gastrointestin Liver Dis. 2011 Mar;20(1):27-31.
BACKGROUND & AIMS: The cornerstone of treatment for coeliac disease is a gluten-free diet (GFD). However, adherence to a GFD is variable. Recently investigators have been reporting their preliminary findings using novel therapies. In addition, there is a growing interest in the use of complementary or alternative medicine (CAM) in gastrointestinal illnesses. These observations suggest that patients with coeliac disease may be dissatisfied with a GFD and possibly are seeking/using alternative therapies for their disease. Our aim was to assess the satisfaction levels of adults with coeliac disease towards a GFD, their use of oral CAM and views regarding novel therapies.
310 patients with coeliac disease completed a questionnaire survey while attending their out-patient appointment. The control group comprised 477 individuals.
Over 40% of patients with coeliac disease were dissatisfied with a GFD. The frequency of CAM use in patients with coeliac disease was 21.6% (67/310) vs 27% in the control group (129/477), p=0.09. All patients expressed an interest in novel therapies, with a vaccine being the first choice in 42% of patients, 35% and 23% for anti- zonulin and peptidases, respectively. Universally, patients placed genetically modified wheat as the lowest preference.
A large proportion of patients with coeliac disease are dissatisfied with a GFD. Coeliac patients are not taking CAM any more than controls, suggesting they do not view CAM as an alternative to a GFD. However, all the patients in this survey were keen to consider novel therapies, with a vaccine being the most preferred option.
治疗乳糜泻的基石是无麸质饮食（GFD）。然而，GFD 的依从性是可变的。最近，研究人员报告了他们使用新疗法的初步发现。此外，人们对胃肠道疾病中使用补充或替代药物（CAM）越来越感兴趣。这些观察结果表明，乳糜泻患者可能对 GFD 不满意，并且可能正在为他们的疾病寻求/使用替代疗法。我们的目的是评估乳糜泻患者对 GFD 的满意度、他们对口服 CAM 的使用以及对新疗法的看法。
310 名乳糜泻患者在就诊时完成了问卷调查。对照组包括 477 人。
超过 40%的乳糜泻患者对 GFD 不满意。乳糜泻患者使用 CAM 的频率为 21.6%（67/310），对照组为 27%（129/477），p=0.09。所有患者都对新疗法表示感兴趣，其中 42%的患者首选疫苗，35%和 23%的患者分别选择抗 zonulin 和肽酶。普遍认为，基因改造小麦是最低的选择。
很大一部分乳糜泻患者对 GFD 不满意。乳糜泻患者没有比对照组更多地使用 CAM，这表明他们不将 CAM 视为 GFD 的替代方法。然而，这项调查中的所有患者都热衷于考虑新的治疗方法，疫苗是最受欢迎的选择。
