六核自组装芳烃-钌纳米棱柱笼：潜在的抗癌剂。
Hexanuclear self-assembled arene-ruthenium nano-prismatic cages: potential anticancer agents.
机构信息
Department of Chemistry, University of Ulsan, Ulsan 680-749, Republic of Korea.
出版信息
Chem Commun (Camb). 2011 May 14;47(18):5184-6. doi: 10.1039/c1cc10167f. Epub 2011 Mar 30.
Abstract
Two novel nano-cage compounds, 8 and 9, were prepared by self-assembly of the ruthenium complexes 4 and 5, and the tripodal donor 1. The cytotoxicity of 8 was found to be considerably stronger than that of cisplatin. The complex 8 inhibited tumor cell proliferation by interfering into regulatory pathways of the cell cycle via apoptosis.
摘要
两种新型纳米笼化合物 8 和 9 通过钌配合物 4 和 5 以及三齿供体 1 的自组装制备。发现 8 的细胞毒性明显强于顺铂。该配合物 8 通过细胞凋亡干扰细胞周期调控途径来抑制肿瘤细胞增殖。
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