口蹄疫病毒RNA生化图谱的重新评估

A re-appraisal of the biochemical map of foot-and-mouth disease virus RNA.

作者信息

Doel T R, Sangar D V, Rowlands D J, Brown F

出版信息

J Gen Virol. 1978 Nov;41(2):395-404. doi: 10.1099/0022-1317-41-2-395.

Abstract

The proteins induced by infection of BHK 21 cells with foot-and-mouth disease virus have been compared by tryptic peptide analysis. The results indicate that there are three primary products 5'--P88, P52, P100--3'. The polypeptide P56, which we considered previously to be a primary product, is derived from the region of the genome that codes for P100. The results indicate that there are alternative cleavage pathways of P100, the polypeptide coded for by the 3' end of the genome.

摘要

通过胰蛋白酶肽分析比较了感染口蹄疫病毒的BHK 21细胞所诱导产生的蛋白质。结果表明存在三种主要产物5'--P88、P52、P100--3'。我们之前认为是主要产物的多肽P56，源自基因组中编码P100的区域。结果表明基因组3'端编码的多肽P100存在多种切割途径。