Kwon Myoung Soo, Hämäläinen Heikki
Department of Psychology, Centre for Cognitive Neuroscience, University of Turku, Finland.
Bioelectromagnetics. 2011 May;32(4):253-72. doi: 10.1002/bem.20635. Epub 2010 Dec 22.
For the last two decades, a large number of studies have investigated the effects of mobile phone radiation on the human brain and cognition using behavioral or neurophysiological measurements. This review evaluated previous findings with respect to study design and data analysis. Provocation studies found no evidence of subjective symptoms attributed to mobile phone radiation, suggesting psychological reasons for inducing such symptoms in hypersensitive people. Behavioral studies previously reported improved cognitive performance under exposure, but it was likely to have occurred by chance due to multiple comparisons. Recent behavioral studies and replication studies with more conservative statistics found no significant effects compared with original studies. Neurophysiological studies found no significant effects on cochlear and brainstem auditory processing, but only inconsistent results on spontaneous and evoked brain electrical activity. The inconsistent findings suggest possible false positives due to multiple comparisons and thus replication is needed. Other approaches such as brain hemodynamic response measurements are promising but the findings are few and not yet conclusive. Rigorous study design and data analysis considering multiple comparisons and effect size are required to reduce controversy in this important field of research.
在过去二十年中，大量研究使用行为或神经生理学测量方法，调查了手机辐射对人类大脑和认知的影响。本综述从研究设计和数据分析方面评估了先前的研究结果。激发研究未发现归因于手机辐射的主观症状的证据，这表明在过敏人群中诱发此类症状存在心理原因。行为学研究此前报告称，暴露环境下认知表现有所改善，但由于多次比较，这很可能是偶然发生的。近期采用更保守统计方法的行为学研究和重复研究发现，与原始研究相比没有显著影响。神经生理学研究未发现对耳蜗和脑干听觉处理有显著影响，仅在自发和诱发脑电活动方面得到了不一致的结果。这些不一致的发现表明，由于多次比较可能存在假阳性结果，因此需要进行重复研究。其他方法，如脑血流动力学反应测量，很有前景，但相关研究较少且尚无定论。需要进行严谨的研究设计和考虑多次比较及效应大小的数据分析，以减少这一重要研究领域的争议。
