Genetically Engineered Materials Science and Engineering, Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195.
ACS Nano. 2009 Jul 28;3(7):1606-15. doi: 10.1021/nn900720g.
With recent developments of nanoscale engineering in the physical and chemical sciences and advances in molecular biology, molecular biomimetics is combining genetic tools and evolutionary approaches with synthetic nanoscale constructs to create a new hybrid methodology: genetically designed peptide-based molecular materials. Following the fundamental principles of genome-based design, molecular recognition, and self-assembly in nature, we can now use recombinant DNA technologies to design single or multifunctional peptides and peptide-based molecular constructs that can interact with solids and synthetic systems. These solid-binding peptides have made significant impact as inorganic synthesizers, nanoparticle linkers, and molecular assemblers, or simply as molecular building blocks, in a wide range of fields from chemistry to materials science to medicine. As part of the programmatic theme, "Nanoscience: Challenges for the Future", the current developments, challenges, and future prospects of the field were presented during a symposium at the 237th ACS National Meeting held in March 2009. This Nano Focus article presents a synopsis of the work discussed there.
随着物理和化学科学中纳米工程的最新发展以及分子生物学的进步，分子仿生学将遗传工具和进化方法与合成纳米结构结合起来，创造了一种新的混合方法：基于基因设计的肽基分子材料。遵循基于基因组设计、分子识别和自然自组装的基本原则，我们现在可以使用重组 DNA 技术来设计能够与固体和合成系统相互作用的单功能或多功能肽和肽基分子构建体。这些与固体结合的肽作为无机合成物、纳米粒子连接物和分子组装体，或者简单地作为分子构建块，在从化学到材料科学再到医学的广泛领域中产生了重大影响。作为“纳米科学：未来的挑战”计划主题的一部分，在 2009 年 3 月举行的第 237 届 ACS 全美会议上的一次专题讨论会上介绍了该领域的最新发展、挑战和未来前景。本文概述了其中的讨论内容。
