Sardinha Aline, Araújo Claudio Gil S, Soares-Filho Gastão Luis Fonseca, Nardi Antonio Egidio
Laboratory of Panic and Respiration, Psychiatry Institute, Federal University of Rio de Janeiro (IPUB/UFRJ), National Institute for Translational Medicine (INCT-TM, CNPq), Rio de Janeiro, Brazil.
Expert Rev Cardiovasc Ther. 2011 Feb;9(2):165-75. doi: 10.1586/erc.10.170.
Psychological factors such as stress and depression have already been established as primary and secondary cardiovascular risk factors. More recently, the role of anxiety in increasing cardiac risk has also been studied. The underlying mechanisms of increased cardiac risk in panic disorder patients seem to reflect the direct and indirect effects of autonomic dysfunction, as well as behavioral risk factors associated with an unhealthy lifestyle. Implications of the comorbidity between panic and cardiovascular disease include higher morbidity, functional deficits, increased cardiovascular risk, and poor adherence to cardiac rehabilitation or exercise programs. This article probes the most recent evidence on the association between coronary artery disease, anxiety and panic disorder, and discusses the potential role of incorporating regular physical exercise and cognitive behavioral therapy in the treatment of this condition.
压力和抑郁等心理因素已被确认为主要和次要的心血管危险因素。最近，焦虑在增加心脏风险方面的作用也得到了研究。惊恐障碍患者心脏风险增加的潜在机制似乎反映了自主神经功能障碍的直接和间接影响，以及与不健康生活方式相关的行为危险因素。惊恐与心血管疾病共病的影响包括更高的发病率、功能缺陷、增加的心血管风险以及对心脏康复或运动计划的依从性差。本文探讨了关于冠状动脉疾病、焦虑和惊恐障碍之间关联的最新证据，并讨论了将定期体育锻炼和认知行为疗法纳入该疾病治疗的潜在作用。
