Nguyen Patricia K, Wu Joseph C
Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305-5111, USA.
Expert Rev Cardiovasc Ther. 2011 Feb;9(2):177-83. doi: 10.1586/erc.10.184.
The increasing exposure to low-dose radiation from diagnostic testing has prompted renewed interest in evaluating its carcinogenic risk, but quantifying health risk from low-dose radiation exposure remains controversial. The current approach is to adopt the linear non-threshold model, which is commonly applied to high-dose exposure, and apply it to assess risk from low-dose exposure. However, existing data are conflicting and limited to epidemiological studies and/or in vitro analyses. In this article, we will discuss the potential cancer risk from low- and high-dose radiation, their effects on DNA repair response pathways, and the best course of action for patients and providers to minimize risk.
诊断检测中低剂量辐射暴露的增加引发了人们对评估其致癌风险的新兴趣，但量化低剂量辐射暴露的健康风险仍存在争议。当前的方法是采用线性无阈模型，该模型通常应用于高剂量暴露，并将其用于评估低剂量暴露的风险。然而，现有数据相互矛盾，且仅限于流行病学研究和/或体外分析。在本文中，我们将讨论低剂量和高剂量辐射的潜在癌症风险、它们对DNA修复反应途径的影响，以及患者和医疗服务提供者将风险降至最低的最佳行动方案。
