泌乳期乳腺淋巴细胞上γ/δ T细胞受体的表达
Expression of gamma/delta T cell receptors on lymphocytes from the lactating mammary gland.
作者信息
Reardon C, Lefrancois L, Farr A, Kubo R, O'Brien R, Born W
机构信息
Department of Dermatology, University of Colorado Health Sciences Center, Denver 80262.
出版信息
J Exp Med. 1990 Oct 1;172(4):1263-6. doi: 10.1084/jem.172.4.1263.
Abstract
gamma/delta cells were at least four times more frequent in lactating mouse mammary glands than among T cells of the most proximal lymph nodes. Two-color staining of freshly isolated T cells and a study of clonally expressed gamma/delta receptors on hybridomas further revealed that the mammary gamma/delta population is heterogeneous, including at least three different subsets, among them cells expressing V gamma 5, V gamma 4 together with V delta 4, or none of these V regions.
摘要
在泌乳小鼠乳腺中，γ/δ细胞的数量至少是最接近的淋巴结T细胞数量的四倍。对新鲜分离的T细胞进行双色染色以及对杂交瘤上克隆表达的γ/δ受体进行研究进一步表明，乳腺γ/δ细胞群体是异质性的，包括至少三个不同的亚群，其中有表达Vγ5、Vγ4和Vδ4的细胞，或不表达这些V区的细胞。
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