Institute of Functional Material Chemistry, Faculty of Chemistry, Northeast Normal University, Changchun, People's Republic of China.
J Colloid Interface Sci. 2011 Jun 1;358(1):109-15. doi: 10.1016/j.jcis.2011.02.023. Epub 2011 Feb 15.
Multifunctional uniform and versatile hollow and rattle-type nanocapsules composed of spindle-shaped Au nanoparticles as cores and fluorescent mesoporous silica shells with tunable optical and fluorescent properties have been developed by controlled etching Au nanorods (AuNRs) coated with mesoporous SiO(2) (AuNR@mSiO(2)) via a small amount of aqua regia (volume ratio HCl/HNO(3)=3/1) as an etching agent in a facile way. The etching process can be tracked by UV-Vis absorption and fluorescence spectroscopy and the size of cavities in the hollow/rattle-type particles can be tuned by controlling the reaction time. The dye molecules incorporated in mSiO(2) walls enabled the nanocapsules to be utilized as a fluorescent imaging agent in cancer cell imaging. Furthermore, such hollow/rattle-structured nanocapsules have the merit of enhanced drug loading capacity acting as carriers for the loading and delivery of an anticancer drug, doxorubicin hydrochloride (DOX), with higher storage for cancer therapy. Herein, the combined functionalities of simultaneous cell imaging and drug delivery of the synthesized nanocapsules have been demonstrated, which provide a very promising candidate for application in optical imaging and drug delivery for cancer cells.
多功能统一且通用的中空和响铃型纳米胶囊，由作为核的纺锤形金纳米颗粒和具有可调谐光学和荧光性质的荧光介孔硅壳组成，通过使用少量王水（体积比 HCl/HNO3=3/1）作为蚀刻剂，通过简便的方法从涂有介孔 SiO2（AuNR@mSiO2）的金纳米棒（AuNR）进行控制蚀刻来制备。可以通过 UV-Vis 吸收和荧光光谱跟踪蚀刻过程，并通过控制反应时间来调节中空/响铃型颗粒中的腔室的尺寸。掺入 mSiO2 壁中的染料分子使纳米胶囊能够用作癌细胞成像中的荧光成像剂。此外，这种中空/响铃结构的纳米胶囊具有增强的药物装载能力的优点，可用作装载和输送盐酸阿霉素（DOX）等抗癌药物的载体，从而具有更高的癌症治疗存储能力。在此，证明了所合成的纳米胶囊的细胞成像和药物输送的双重功能，为在癌细胞的光学成像和药物输送中应用提供了很有前途的候选物。
