高尔基体信号传递。
Signaling at the Golgi.
机构信息
Division of Nephrology and Hypertension and Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, OR 97239, USA.
出版信息
Cold Spring Harb Perspect Biol. 2011 May 1;3(5):a005314. doi: 10.1101/cshperspect.a005314.
Abstract
The protein processing and trafficking function of the Golgi is intimately linked to multiple intracellular signaling pathways. Assembly of Golgi trafficking structures and lipid sorting at the Golgi complex is controlled and coordinated by specific phosphoinositide kinases and phosphatases. The intra-Golgi transport machinery is also regulated by kinases belonging to several functionally distinct families, for example, MAP kinase signaling is required for mitotic disassembly of the Golgi. However, the Golgi plays an additional, prominent role in compartmentalizing other signaling cascades that originate at the plasma membrane or at other organelles. This article summarizes recent advances in our understanding of the signaling network that converges at the Golgi.
摘要
高尔基体的蛋白质加工和运输功能与多种细胞内信号通路密切相关。高尔基体运输结构的组装和脂质在高尔基复合体中的分拣是由特定的磷酸肌醇激酶和磷酸酶控制和协调的。高尔基体内部运输机制也受到属于几个功能不同家族的激酶的调节，例如，MAP 激酶信号通路对于有丝分裂过程中高尔基体的解体是必需的。然而，高尔基体在分隔其他信号级联反应中也发挥着重要作用，这些信号级联反应起始于质膜或其他细胞器。本文总结了我们在理解汇聚到高尔基体的信号网络方面的最新进展。
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