Institute of Biochemistry and Cell Biology, National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy.
Institute for Endocrinology and Experimental Oncology "G. Salvatore", National Research Council, 80131 Naples, Italy.
Cells. 2022 Jun 21;11(13):1990. doi: 10.3390/cells11131990.
The Golgi Complex is the central hub in the endomembrane system and serves not only as a biosynthetic and processing center but also as a trafficking and sorting station for glycoproteins and lipids. In addition, it is an active signaling hub involved in the regulation of multiple cellular processes, including cell polarity, motility, growth, autophagy, apoptosis, inflammation, DNA repair and stress responses. As such, the dysregulation of the Golgi Complex-centered signaling cascades contributes to the onset of several pathological conditions, including cancer. This review summarizes the current knowledge on the signaling pathways regulated by the Golgi Complex and implicated in promoting cancer hallmarks and tumor progression.
高尔基复合体是内质网系统的中心枢纽，不仅是生物合成和加工中心，也是糖蛋白和脂质的运输和分拣站。此外，它还是一个活跃的信号枢纽，参与调节多种细胞过程，包括细胞极性、运动、生长、自噬、细胞凋亡、炎症、DNA 修复和应激反应。因此，高尔基复合体中心信号级联的失调导致了几种病理状况的发生，包括癌症。本综述总结了目前关于高尔基复合体调节的信号通路的知识，并探讨了其在促进癌症特征和肿瘤进展中的作用。
