Eshete Mekonen, Gravenm Paul Egil, Topstad Thom, Befikadu Sisay
Yekatit 12 Hospital Burn/CLP project, P.O. Box 17763.
Ethiop Med J. 2011 Jan;49(1):1-5.
Cleft lip and cleft palate are among the most common oro-facial anomalies. For various reasons, cleft lip and cleft palate patients have never been given priority by health planners in most African countries including Ethiopia. Lack of data about the incidence of this anomaly might have contributed to the poor understanding and care of these patients in our country.
The main objective of this study is to determine the incidence of cleft lip and palate in Addis Ababa.
This is a prospective survey carried out between September 1, 2004 and February 28, 2007. Seven health institutions in Addis Ababa giving delivery service were utilized for this study purpose. All live births were evaluated by trained staff for presence of cleft lip and palate anomalies.
The number of live births was 42,986. Sixty-four new cleft lip and palate patients were recorded in the study institutions which gives an incidence of 1.49/1000 live births or 1 in 672 live births. The female:male ratio was 1:0.6. in the cleft lip group, 1:1.8 in the cleft lip and palate group, and 1:0.5 in the cleft palate group. A family history of clefts was recorded in three babies (4.8% of cleft patients), one in cleft lip alone (1.6%) and two in cleft lip and palate (3.1%). In ten of the clefts there were associated anomalies: extremity malformation in five (Syndactyly in two, popliteal webbing polvdactyly and a congenital constricting band), central nervous malformations in three, genital malformation in one and heart anomaly in one tetralogy of Fallot (TOF) echocardiography proved.
The incidence found in this study indicates that cleft is not rare in our country 64 (1.49/1000). As many African babies are born outside hospital the results of a more extensive audit would be valuable.
唇腭裂是最常见的口腔面部畸形之一。由于各种原因，在包括埃塞俄比亚在内的大多数非洲国家，唇腭裂患者从未被卫生规划者列为优先关注对象。缺乏关于这种畸形发病率的数据可能导致了我国对这些患者的了解和护理不足。
本研究的主要目的是确定亚的斯亚贝巴唇腭裂的发病率。
这是一项于2004年9月1日至2007年2月28日进行的前瞻性调查。本研究利用了亚的斯亚贝巴提供分娩服务的七家医疗机构。所有活产婴儿均由经过培训的工作人员评估是否存在唇腭裂畸形。
活产婴儿数量为42986例。研究机构记录了64例新的唇腭裂患者，发病率为1.49/1000活产婴儿，即672例活产婴儿中有1例患病。女性与男性的比例为1:0.6。在唇裂组中为1:1.8，在唇腭裂组中为1:0.5，在腭裂组中为1:0.5。有三名婴儿（占腭裂患者的4.8%）有腭裂家族史，其中一名仅为唇裂（1.6%），两名患有唇腭裂（3.1%）。在10例腭裂病例中存在相关畸形：5例肢体畸形（2例并指、腘窝蹼状多指畸形和1例先天性束带），3例中枢神经系统畸形，1例生殖器畸形，1例法洛四联症（TOF）心脏异常（经超声心动图证实）。
本研究发现的发病率表明，唇腭裂在我国并不罕见（64例，1.49/1000）。由于许多非洲婴儿是在医院外出生
