Provident Clinical Research, Glen Ellyn, Illinois, USA.
Diabetes Technol Ther. 2011 Jun;13(6):661-6. doi: 10.1089/dia.2010.0240. Epub 2011 Apr 2.
A liquid meal tolerance test (LMTT) has been proposed as a useful alternative to more labor-intensive methods of assessing insulin sensitivity and secretion.
This substudy, conducted at the conclusion of a randomized, double-blind crossover trial, compared insulin sensitivity indices from a LMTT (Matsuda insulin sensitivity index [MISI] and LMTT disposition index [LMTT-DI]) with indices derived from minimal model analysis of results from the insulin-modified intravenous glucose tolerance test (IVGTT) (insulin sensitivity index [S(I)] and disposition index [DI]).
Participants included men (n = 16) and women (n = 8) without diabetes but with increased abdominal adiposity (waist circumference ≥102 cm and ≥89 cm, respectively) and mean age of 48.9 years. The correlation between S(I) and the MISI was 0.776 (P < 0.0001). The respective associations between S(I) and MISI with waist circumference (r = -0.445 and -0.554, both P < 0.05) and body mass index were similar (r = -0.500 and -0.539, P < 0.05). The correlation between DI and LMTT-DI was 0.604 (P = 0.002).
These results indicate that indices of insulin sensitivity and secretion derived from the LMTT correlate well with those from the insulin-modified IVGTT with minimal model analysis, suggesting that they may be useful for application in clinical and population studies of glucose homeostasis.
液体餐耐量试验（LMTT）已被提出作为评估胰岛素敏感性和分泌的更具劳动密集性方法的有用替代方法。
本亚研究在一项随机、双盲交叉试验结束时进行，比较了 LMTT（Matsuda 胰岛素敏感性指数[MISI]和 LMTT 处置指数[LMTT-DI]）和胰岛素改良静脉葡萄糖耐量试验（IVGTT）结果的最小模型分析得出的胰岛素敏感性指数（S（I）和处置指数[DI]。
参与者包括无糖尿病但腹部肥胖增加的男性（n=16）和女性（腰围分别≥102cm 和≥89cm），平均年龄为 48.9 岁。S（I）与 MISI 之间的相关性为 0.776（P<0.0001）。S（I）与 MISI 分别与腰围（r=-0.445 和-0.554，均 P<0.05）和体重指数的相关性相似（r=-0.500 和-0.539，P<0.05）。DI 与 LMTT-DI 之间的相关性为 0.604（P=0.002）。
这些结果表明，LMTT 得出的胰岛素敏感性和分泌指数与胰岛素改良 IVGTT 最小模型分析得出的指数相关性良好，表明它们可能在葡萄糖稳态的临床和人群研究中有用。
