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kisspeptin 对人类胰岛β细胞功能、血清代谢物和食欲的影响。

The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans.

机构信息

Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.

Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK.

出版信息

Diabetes Obes Metab. 2018 Dec;20(12):2800-2810. doi: 10.1111/dom.13460. Epub 2018 Aug 16.

DOI:10.1111/dom.13460
PMID:29974637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6282711/
Abstract

AIMS

To investigate the effect of kisspeptin on glucose-stimulated insulin secretion and appetite in humans.

MATERIALS AND METHODS

In 15 healthy men (age: 25.2 ± 1.1 years; BMI: 22.3 ± 0.5 kg m ), we compared the effects of 1 nmol kg h kisspeptin versus vehicle administration on glucose-stimulated insulin secretion, metabolites, gut hormones, appetite and food intake. In addition, we assessed the effect of kisspeptin on glucose-stimulated insulin secretion in vitro in human pancreatic islets and a human β-cell line (EndoC-βH1 cells).

RESULTS

Kisspeptin administration to healthy men enhanced insulin secretion following an intravenous glucose load, and modulated serum metabolites. In keeping with this, kisspeptin increased glucose-stimulated insulin secretion from human islets and a human pancreatic cell line in vitro. In addition, kisspeptin administration did not alter gut hormones, appetite or food intake in healthy men.

CONCLUSIONS

Collectively, these data demonstrate for the first time a beneficial role for kisspeptin in insulin secretion in humans in vivo. This has important implications for our understanding of the links between reproduction and metabolism in humans, as well as for the ongoing translational development of kisspeptin-based therapies for reproductive and potentially metabolic conditions.

摘要

目的

研究 kisspeptin 对人体葡萄糖刺激胰岛素分泌和食欲的影响。

材料和方法

在 15 名健康男性（年龄：25.2±1.1 岁；BMI：22.3±0.5kg/m²）中，我们比较了 1nmol/kg/h kisspeptin 与载体给药对葡萄糖刺激胰岛素分泌、代谢物、肠道激素、食欲和食物摄入的影响。此外，我们评估了 kisspeptin 对人胰岛和人β细胞系（EndoC-βH1 细胞）中葡萄糖刺激胰岛素分泌的体外作用。

结果

向健康男性给予 kisspeptin 可增强静脉葡萄糖负荷后的胰岛素分泌，并调节血清代谢物。与此一致的是，kisspeptin 增加了体外人胰岛和人胰腺细胞系的葡萄糖刺激胰岛素分泌。此外，kisspeptin 给药并未改变健康男性的肠道激素、食欲或食物摄入。

结论

这些数据首次证明 kisspeptin 在人体体内胰岛素分泌中具有有益作用。这对我们理解人类生殖和代谢之间的联系具有重要意义，也为基于 kisspeptin 的治疗生殖和潜在代谢疾病的持续转化发展提供了依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fcd/6282711/604ed789dcc8/DOM-20-2800-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fcd/6282711/9c077ff6d7eb/DOM-20-2800-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fcd/6282711/1972fd4f7562/DOM-20-2800-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fcd/6282711/3c72ed5a7e3e/DOM-20-2800-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fcd/6282711/604ed789dcc8/DOM-20-2800-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fcd/6282711/9c077ff6d7eb/DOM-20-2800-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fcd/6282711/1972fd4f7562/DOM-20-2800-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fcd/6282711/3c72ed5a7e3e/DOM-20-2800-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fcd/6282711/604ed789dcc8/DOM-20-2800-g001.jpg

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