Institut für Biochemie, Universitätsmedizin Berlin, Charité, Berlin 13347, Germany.
Biochem Biophys Res Commun. 2011 Apr 29;408(1):65-70. doi: 10.1016/j.bbrc.2011.03.117. Epub 2011 Mar 30.
Immunoproteasome has been associated to neurodegenerative and autoimmune diseases as a marker and regulator of inflammatory mechanisms. Its expression in the brain may occur upon neuroinflammation in different cell types and affect a variety of homeostatic and inflammatory pathways including the oxidized protein clearance and the self-antigen presentation. In the present study we investigated the immunoproteasome expression in hippocampi and cortex of patients affected by different histopathological forms of pharmaco-resistent mesial temporal lobe epilepsy. We identified a pathology-specific pattern of immunoproteasome expression, which could provide insight into the complex neuroinflammatory pathogenic components of this disease.
免疫蛋白酶体与神经退行性和自身免疫性疾病有关，是炎症机制的标志物和调节剂。它在大脑中的表达可能发生在不同细胞类型的神经炎症中，并影响多种动态平衡和炎症途径，包括氧化蛋白清除和自身抗原呈递。在本研究中，我们研究了不同组织病理学形式的药物难治性颞叶内侧癫痫患者海马和皮质中的免疫蛋白酶体表达。我们确定了免疫蛋白酶体表达的特定病理模式，这可以深入了解这种疾病的复杂神经炎症发病成分。
