The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.
Cell. 2011 Apr 1;145(1):30-8. doi: 10.1016/j.cell.2011.03.020.
As cancer cell genomes are unveiled at a breathtaking pace, the genetic principles at play in cancer are emerging in all their complexity, prompting the assessment of classical genetic interaction models. Here, we discuss the implications of these findings for cancer progression and heterogeneity and for the development of new therapeutic approaches.
随着癌症细胞基因组的快速揭示，癌症中发挥作用的遗传原则以其复杂性显现出来，促使人们对经典的遗传相互作用模型进行评估。在这里，我们讨论了这些发现对癌症进展和异质性以及新治疗方法的发展的影响。
