经 TMS 治疗后，听觉幻觉改善，初级听觉区激活减少。
Improvement of auditory hallucinations and reduction of primary auditory area's activation following TMS.
机构信息
German Cancer Research Center, Heidelberg, Germany.
出版信息
Eur J Radiol. 2012 Jun;81(6):1273-5. doi: 10.1016/j.ejrad.2011.03.002. Epub 2011 Apr 3.
BACKGROUND
In the present case study, improvement of auditory hallucinations following transcranial magnetic stimulation (TMS) therapy was investigated with respect to activation changes of the auditory cortices.
METHODS
Using functional magnetic resonance imaging (fMRI), activation of the auditory cortices was assessed prior to and after a 4-week TMS series of the left superior temporal gyrus in a schizophrenic patient with medication-resistant auditory hallucinations.
RESULTS
Hallucinations decreased slightly after the third and profoundly after the fourth week of TMS. Activation in the primary auditory area decreased, whereas activation in the operculum and insula remained stable.
CONCLUSIONS
Combination of TMS and repetitive fMRI is promising to elucidate the physiological changes induced by TMS.
背景
在本病例研究中，我们探讨了经颅磁刺激（TMS）治疗后听觉幻觉改善与听觉皮层激活变化之间的关系。
方法
我们使用功能磁共振成像（fMRI）技术，在一名药物难治性听觉幻觉的精神分裂症患者接受为期 4 周的左侧上颞叶 TMS 治疗前后，评估了听觉皮层的激活情况。
结果
在 TMS 治疗的第 3 周和第 4 周后，幻觉略有减轻。初级听觉区的激活减少，而脑岛和岛盖部的激活保持稳定。
结论
TMS 与重复 fMRI 的结合有望阐明 TMS 诱导的生理变化。
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