Department of Pathology, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA.
PPAR Res. 2010;2010:153252. doi: 10.1155/2010/153252. Epub 2011 Feb 24.
Isoflavone intake through foods and dietary supplements has both health advocates and critics. The latter come from a concern about the estrogenic effects of isoflavones in certain species. However, careful removal of isoflavones and other estrogens from the diet of rodents leads to the metabolic syndrome. These results suggest that isoflavones have other mechanisms of action, potentially those involving regulation of fatty acid metabolism via the nuclear receptors PPARα and PPARγ. The goal of this paper was to examine the evidence for isoflavone/PPAR signaling and to identify diseases in which such signaling would have an important impact. It is therefore of note that investigators using a chemical structure approach to discover PPAR ligands identified isoflavones as the best structures in the library of compounds that they tested. Future studies will involve careful identification of the underlying mechanisms whereby isoflavones have their action via PPAR signaling.
异黄酮通过食物和膳食补充剂的摄入，既有其拥护者，也有其批评者。后者主要是因为担心某些物种的异黄酮具有雌激素作用。然而，通过精心从啮齿动物的饮食中去除异黄酮和其他雌激素，会导致代谢综合征。这些结果表明，异黄酮可能具有其他作用机制，可能涉及通过核受体 PPARα 和 PPARγ 调节脂肪酸代谢。本文的目的是检验异黄酮/PPAR 信号的证据，并确定在哪些疾病中这种信号将产生重要影响。因此值得注意的是，研究人员使用化学结构方法来发现 PPAR 配体，他们在测试的化合物库中发现异黄酮是最好的结构。未来的研究将涉及仔细确定异黄酮通过 PPAR 信号发挥作用的潜在机制。
