Bahari Hossein, Shahraki Jazinaki Mostafa, Rahnama Iman, Aghakhani Ladan, Amini Mohammad Reza, Malekahmadi Mahsa
Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Front Nutr. 2024 Dec 12;11:1454286. doi: 10.3389/fnut.2024.1454286. eCollection 2024.
This systematic review and meta-analysis examine the effects of okra consumption on cardiometabolic risk factors in individuals with prediabetes and diabetes. Okra is a widely consumed vegetable with potential health benefits, and understanding its impact on metabolic parameters in these populations is important.
A comprehensive search of the literature was conducted up to May 2024 in PubMed/Medline, Scopus, and Web of Science to find relevant randomized clinical trials (RCTs) by using following keyword: ("okra" OR "okras" OR "") AND ("intervention" OR "controlled trial" OR "randomized" OR "randomized" OR "randomly" OR "clinical trial" OR "trial" OR "randomized controlled trial" OR "randomized clinical trial" OR "RCT" OR "blinded" OR "placebo" OR "Cross-Over" OR "parallel"). The selected trials were subjected to heterogeneity tests using the I statistic. Random effects models were examined based on the heterogeneity tests, and the pooled data were calculated as weighted mean differences (WMD) with a 95% confidence interval (CI). In this meta-analysis, all the analyses were performed by using the STATA version 17 software.
Of the 1,339 papers, nine eligible RCTs were included in the present meta-analysis. Our findings indicated that okra consumption significantly reduced total cholesterol (TC) levels (WMD: -14.40 mg/dL; (95% CI: -20.94 to -7.86); < 0.001), low-density lipoprotein (LDL) (WMD: -7.90 mg/dL; (95% CI: -13.30 to -2.48); = 0.004), fasting blood glucose (FBG) (WMD: -39.58 mg/dL; (95% CI: -61.60 to -17.56); < 0.001), and hemoglobin A1C (HbA1c) (WMD: -0.46 mg/dL; (95% CI: -0.79 to -0.13); = 0.005). Overall effect size showed that okra intake failed to change triglycerides (TG), high-density lipoprotein (HDL), Insulin, homeostatic model assessment for insulin resistance (HOMA-IR), systolic blood pressure (SBP), diastolic blood pressure (DBP), body weight, and body Mass Index (BMI) significantly.
Okra decreased TC, LDL, FBG, and HbA1c levels in the intervention compared to the control group. A dose ≤3,000 mg/day caused a significant decrease in TG, TC, LDL, HbA1c, and a significant increase in HDL. More study is needed to determine the optimum dose and duration of intervention.
本系统评价和荟萃分析探讨食用秋葵对糖尿病前期和糖尿病患者心血管代谢危险因素的影响。秋葵是一种广泛食用的蔬菜，具有潜在的健康益处，了解其对这些人群代谢参数的影响很重要。
截至2024年5月，在PubMed/Medline、Scopus和Web of Science中对文献进行全面检索，以使用以下关键词找到相关的随机临床试验（RCT）：（“秋葵”或“秋葵属”或“”）以及（“干预”或“对照试验”或“随机”或“随机化”或“随机地”或“临床试验”或“试验”或“随机对照试验”或“随机临床试验”或“RCT”或“盲法”或“安慰剂”或“交叉”或“平行”）。使用I统计量对所选试验进行异质性检验。基于异质性检验检查随机效应模型，并将汇总数据计算为加权平均差（WMD），置信区间为95%（CI）。在本荟萃分析中，所有分析均使用STATA 17软件进行。
在1339篇论文中，本荟萃分析纳入了9项符合条件的RCT。我们的研究结果表明，食用秋葵可显著降低总胆固醇（TC）水平（WMD：-14.40mg/dL；（95%CI：-20.94至-7.86）；P<0.001）、低密度脂蛋白（LDL）（WMD：-7.90mg/dL；（95%CI：-13.30至-2.48）；P = 0.004）、空腹血糖（FBG）（WMD：-39.58mg/dL；（95%CI：-61.60至-17.56）；P<0.001）和糖化血红蛋白（HbA1c）（WMD：-0.46mg/dL；（95%CI：-0.79至-0.13）；P = 0.005）。总体效应量表明，摄入秋葵未能显著改变甘油三酯（TG）、高密度脂蛋白（HDL）、胰岛素、胰岛素抵抗稳态模型评估（HOMA-IR）、收缩压（SBP）、舒张压（DBP）、体重和体重指数（BMI）。
与对照组相比，秋葵在干预组中降低了TC、LDL、FBG和HbA1c水平。剂量≤3000mg/天可显著降低TG、TC、LDL、HbA1c，并显著升高HDL。需要更多研究来确定最佳干预剂量和持续时间。
