Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Allergy Asthma Immunol Res. 2011 Apr;3(2):103-10. doi: 10.4168/aair.2011.3.2.103. Epub 2011 Feb 14.
Allergic rhinitis is clinically defined as a disorder of the nose induced by IgE mediated inflammation after allergen exposure of the nasal mucosa. Many reports have stated that Panax ginseng and fermented red ginseng have anti-inflammatory effects, especially against Th2-type inflammation. This study was conducted to evaluate the therapeutic effects of fermented red ginseng in allergic rhinitis.
In this 4-week, double-blind, placebo-controlled study, 59 patients with persistent perennial allergic rhinitis were randomly divided into two groups: those receiving fermented red ginseng tablets (experimental group) and those receiving placebo (control group). The primary efficacy variable was the total nasal symptom score (TNSS; rhinorrhea, sneezing, itchy nose, and nasal congestion). Secondary efficacy variables were the Rhinitis Quality of Life (RQoL) score and skin reactivity to inhalant allergens, as determined by the skin prick test.
There was no significant difference in the TNSS score and TNSS duration score between the experimental and placebo groups in weeks 1, 2, 3, or 4. For nasal congestion, fermented red ginseng was significantly effective (P<0.005), while placebo caused no change. The activity and emotion of RQoL improved markedly secondary to treatment with fermented red ginseng (P<0.05), while placebo caused no change. Additionally, fermented red ginseng reduced skin reactivity to sensitized perennial allergens (P<0.05). Fermented red ginseng was well tolerated.
Fermented red ginseng improved nasal congestion symptoms and RQoL in patients with perennial allergic rhinitis.
变应性鼻炎临床上被定义为鼻黏膜在过敏原暴露后，由 IgE 介导的炎症引起的鼻部疾病。许多报道指出，人参和发酵红参具有抗炎作用，特别是针对 Th2 型炎症。本研究旨在评估发酵红参治疗变应性鼻炎的疗效。
在这项为期 4 周的双盲、安慰剂对照研究中，59 例持续性常年性变应性鼻炎患者被随机分为两组：接受发酵红参片（实验组）和接受安慰剂（对照组）。主要疗效变量是总鼻部症状评分（TNSS；流涕、打喷嚏、鼻痒和鼻塞）。次要疗效变量是鼻炎生活质量（RQoL）评分和皮肤对吸入性过敏原的反应性，通过皮肤点刺试验确定。
在第 1、2、3 和 4 周，实验组和对照组的 TNSS 评分和 TNSS 持续时间评分均无显著差异。对于鼻塞，发酵红参具有显著疗效（P<0.005），而安慰剂则无变化。RQoL 的活动和情绪因发酵红参的治疗而明显改善（P<0.05），而安慰剂则无变化。此外，发酵红参降低了对致敏常年过敏原的皮肤反应性（P<0.05）。发酵红参耐受性良好。
发酵红参可改善常年性变应性鼻炎患者的鼻塞症状和 RQoL。
