Biozentrum, Division of Pharmacology/Neurobiology, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland.
Diabetologia. 2011 Jun;54(6):1270-2. doi: 10.1007/s00125-011-2135-3. Epub 2011 Apr 2.
Proteins belonging to the peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) family are key regulators of cellular energy homeostasis in a number of oxidative tissues, including skeletal muscle. While the regulation and function of PGC-1α seems central to muscle fibre plasticity in endurance exercise, the role of PGC-1β in this tissue is less clear. Wright et al. (Diabetologia, DOI: 10.1007/s00125-011-2068-x ) provide evidence for a protective effect of moderately elevated PGC-1β in electroporated rat skeletal muscle against high-fat-diet-induced insulin resistance, at least in part by promoting the oxidation of long chain acyl-CoA entities and the elimination of reactive oxygen species. These data provide important insights into the biological role of PGC-1β in skeletal muscle and imply novel therapeutic avenues for improving peripheral insulin sensitivity.
属于过氧化物酶体增殖物激活受体 γ 共激活因子 1（PGC-1）家族的蛋白质是许多氧化组织中细胞能量稳态的关键调节剂，包括骨骼肌。虽然 PGC-1α 的调节和功能似乎对耐力运动中的肌肉纤维可塑性至关重要，但 PGC-1β 在这种组织中的作用尚不明确。Wright 等人（《糖尿病学》，DOI: 10.1007/s00125-011-2068-x）提供了证据，证明中度升高的电穿孔大鼠骨骼肌中的 PGC-1β 对高脂肪饮食诱导的胰岛素抵抗具有保护作用，至少部分是通过促进长链酰基辅酶 A 实体的氧化和消除活性氧来实现的。这些数据为 PGC-1β 在骨骼肌中的生物学作用提供了重要的见解，并暗示了改善外周胰岛素敏感性的新的治疗途径。
