Dipartimento di Chimica, Materiali e Ingegneria Chimica G. Natta, Politecnico di Milano, Via Mancinelli 7, 20131, Milan, Italy.
J Mater Sci Mater Med. 2011 May;22(5):1303-19. doi: 10.1007/s10856-011-4307-6. Epub 2011 Apr 3.
The high-velocity suspension flame spraying technique (HVSFS) was employed in order to deposit 45S5 bioactive glass coatings onto titanium substrates, using a suspension of micron-sized glass powders dispersed in a water + isopropanol mixture as feedstock. By modifying the process parameters, five coatings with different thickness and porosity were obtained. The coatings were entirely glassy but exhibited a through-thickness microstructural gradient, as the deposition mechanisms of the glass droplets changed at every torch cycle because of the increase in the system temperature during spraying. After soaking in simulated body fluid, all of the coatings were soon covered by a layer of hydroxyapatite; furthermore, the coatings exhibited no cytotoxicity and human osteosarcoma cells could adhere and proliferate well onto their surfaces. HVSFS-deposited 45S5 bioglass coatings are therefore highly bioactive and have potentials as replacement of conventional hydroxyapatite in order to favour osseointegration of dental and prosthetic implants.
采用高速悬浮火焰喷涂技术（HVSFS），通过将微米级玻璃粉末分散在水+异丙醇混合物中的悬浮液作为原料，在钛基体上沉积 45S5 生物活性玻璃涂层。通过改变工艺参数，获得了五种不同厚度和孔隙率的涂层。这些涂层完全为玻璃态，但表现出贯穿厚度的微观结构梯度，因为在喷涂过程中由于系统温度的升高，玻璃液滴的沉积机制在每个火炬周期都会发生变化。在模拟体液中浸泡后，所有涂层很快就被一层羟基磷灰石覆盖；此外，这些涂层没有细胞毒性，人骨肉瘤细胞可以很好地附着和增殖在其表面。因此，HVSFS 沉积的 45S5 生物玻璃涂层具有高度的生物活性，并有可能替代传统的羟基磷灰石，以促进牙科和植入物的骨整合。
