Department of Urology, Institute of Urology, Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
Sci Rep. 2021 May 25;11(1):10833. doi: 10.1038/s41598-021-90404-2.
To update the current evidence on whether hepatitis C virus (HCV) infection represents a possible risk factor for renal cell cancer (RCC), prostate cancer (PCa), and bladder cancer (BC). We searched the literature on Pubmed, Web of Science, and Embases before April 2021. A systematic review and meta-analysis were performed. Finally, we extracted 12 studies based on the eligible criteria. Across 11 studies for HCV and RCC, the incorporated RR was 1.28 (95% CI 1.05-1.55), which meant that participants with HCV infection were associated with higher RCC risk. The pooled RR in hazard ratio (HR) subgroup (HR 1.59, 95% CI 1.22-2.08), cohort studies subgroup (RR 1.47, 95% CI 1.18-1.82), and North America subgroup (RR 1.71, 95% CI 1.40-2.09) detected a stronger association between HCV and RCC risk. Although an inverse association was seen for PCa (RR 0.75, 95% CI 0.54-1.03) across seven studies, it was not statistically significant (P = 0.075). There was no significant association between HCV and BC with an incorporated RR of 0.92 (95% CI, 0.82-1.03) across five studies. Our study demonstrated that HCV infection was significantly associated with increased RCC risk. There appeared to be an inverse association for HCV in PCa risk but not statistically significant. No significant association was found between HCV and BC risk. Prospective, large-scale, and well-designed cohort studies are required to validate the association between HCV and RCC, and to investigate the role of HCV on PCa.
为了更新当前的证据，即丙型肝炎病毒（HCV）感染是否是肾癌（RCC）、前列腺癌（PCa）和膀胱癌（BC）的一个可能的危险因素。我们在 2021 年 4 月之前在 Pubmed、Web of Science 和 Embase 上搜索了文献。进行了系统评价和荟萃分析。最后，我们根据合格标准提取了 12 项研究。在 11 项关于 HCV 和 RCC 的研究中，合并 RR 为 1.28（95%CI 1.05-1.55），这意味着 HCV 感染的参与者患 RCC 的风险更高。在危险比（HR）亚组（HR 1.59，95%CI 1.22-2.08）、队列研究亚组（RR 1.47，95%CI 1.18-1.82）和北美亚组（RR 1.71，95%CI 1.40-2.09）中，检测到 HCV 与 RCC 风险之间存在更强的关联。尽管在 7 项研究中，PCa 呈负相关（RR 0.75，95%CI 0.54-1.03），但没有统计学意义（P=0.075）。在 5 项研究中，HCV 与 BC 之间没有显著关联，合并 RR 为 0.92（95%CI，0.82-1.03）。我们的研究表明，HCV 感染与 RCC 风险增加显著相关。在 PCa 风险方面，HCV 似乎呈负相关，但没有统计学意义。HCV 与 BC 风险之间没有发现显著关联。需要进行前瞻性、大规模和精心设计的队列研究，以验证 HCV 与 RCC 之间的关联，并研究 HCV 在 PCa 中的作用。
