Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Nat Prod Res. 2011 Sep;25(15):1469-72. doi: 10.1080/14786419.2011.557800. Epub 2011 Jul 11.
This study was designed to investigate possible antidepressant-like effects of the extract prepared from the flowers of Hypericum montbretti Spach. (Guttiferae, Clusiaceae). Phytochemical constituents of the methanolic extract were analysed by HPLC method. The main flavonoid component was detected as rutin, and another highly concentrated phenolic compound was quercitrin. Antidepressant activity of the extract was examined by tail suspension and modified forced swimming tests, whereas the motor coordination of the animals was tested by the Rota-Rod apparatus. Reboxetine at a dose of 20 mg kg⁻¹ was used as a reference drug. Dose-dependent antidepressant activity was observed in both tests following the administration of extract at 100 and 250 mg kg⁻¹ doses. To the best of our knowledge, this is the first study reporting the antidepressant activity of H. montbretti extract. Additionally, the results of this work support previous papers reporting the antidepressant activity of rutin.
本研究旨在探讨由 Hypericum montbretti Spach.（藤黄科）花制备的提取物可能具有的抗抑郁作用。采用高效液相色谱法分析了甲醇提取物的化学成分。主要黄酮类成分为芦丁，另一种高度浓缩的酚类化合物为槲皮素。通过悬尾和改良强迫游泳试验检测提取物的抗抑郁活性，而通过转棒仪测试动物的运动协调能力。瑞波西汀 20mg/kg 被用作参考药物。在给予 100 和 250mg/kg 剂量的提取物后，在这两种试验中均观察到剂量依赖性的抗抑郁活性。据我们所知，这是首次报道 H. montbretti 提取物具有抗抑郁作用的研究。此外，本工作的结果支持了先前报道芦丁具有抗抑郁活性的论文。
