Henri Samueli School of Engineering and Applied Science, Biomedical Inter-Department Program, University of California-Los Angeles, Los Angeles, CA 90095-1597, USA.
J Biophotonics. 2011 Aug;4(7-8):565-76. doi: 10.1002/jbio.201000117. Epub 2011 Apr 1.
This study combines non-invasive hyperspectral imaging with an experimentally validated skin optical model and inverse algorithm to monitor diabetic feet of two representative patients. It aims to observe temporal changes in local epidermal thickness and oxyhemoglobin concentration and to gain insight into the progression of foot ulcer formation and healing. Foot ulceration is a debilitating comorbidity of diabetes that may result in loss of mobility and amputation. Inflammation and necrosis preempt ulceration and can result in changes in the skin prior to ulceration and during ulcer healing that affect oxygen delivery and consumption. Previous studies estimated oxyhemoglobin and deoxyhemoglobin concentrations around pre-ulcerative and ulcer sites on the diabetic foot using commercially available hyperspectral imaging systems. These measurements were successfully used to detect tissue at risk of ulceration and predict the healing potential of ulcers. The present study shows epidermal thickening and decrease in oxyhemoglobin concentration can also be detected prior to ulceration at pre-ulcerative sites. The algorithm was also able to observe reduction in the epidermal thickness combined with an increase in oxyhemoglobin concentration around the ulcer as it healed and closed. This methodology can be used for early prediction of diabetic foot ulceration in a clinical setting.
本研究结合了非侵入性的高光谱成像技术、经实验验证的皮肤光学模型和反演算法，以监测两名代表性糖尿病患者的脚部情况。该研究旨在观察局部表皮厚度和氧合血红蛋白浓度的时间变化，深入了解足部溃疡形成和愈合的进展。足部溃疡是糖尿病的一种严重并发症，可能导致行动不便和截肢。炎症和坏死会引发溃疡，在溃疡形成之前和愈合过程中，皮肤会发生变化，从而影响氧气的输送和消耗。先前的研究使用市售的高光谱成像系统，对糖尿病足的前溃疡和溃疡部位周围的氧合血红蛋白和脱氧血红蛋白浓度进行了估计。这些测量结果成功地用于检测有溃疡风险的组织，并预测溃疡的愈合潜力。本研究表明，在溃疡前的前溃疡部位，也可以检测到表皮增厚和氧合血红蛋白浓度降低。该算法还能够观察到随着溃疡愈合和闭合，溃疡周围的表皮厚度减少，同时氧合血红蛋白浓度增加。该方法可用于临床环境中对糖尿病足溃疡的早期预测。
