Leiva Kevin, Gonzalez Isabella, Murillo Juan, Espinosa Aliette, Kirsner Robert S, Godavarty Anuradha
Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA.
Phillip Frost Department of Dermatology & Cutaneous Surgery, UM Wound Care Center, University of Miami, Miami, FL 33136, USA.
Bioengineering (Basel). 2024 Dec 3;11(12):1221. doi: 10.3390/bioengineering11121221.
A mammalian breath-hold (BH) mechanism can induce vasoconstriction in the limbs, altering blood flow and oxygenation flow changes in a wound site. Our objective was to utilize a BH paradigm as a stimulus to induce peripheral tissue oxygenation changes via studies on control and diabetic foot ulcer (DFU) subjects. Subjects were imaged under a breath-hold paradigm (including 20 s BH) using a non-contact spatio-temporal-based NIRS device. Oxygenated flow changes were similar between darker and lighter skin colors but differed between wound site and normal background tissues. Thus, the ability of peripheral vasculature to response to oxygenation demand can be assessed in DFUs.
哺乳动物的屏气（BH）机制可诱导四肢血管收缩，改变伤口部位的血流和氧合血流变化。我们的目标是通过对对照组和糖尿病足溃疡（DFU）患者的研究，利用屏气模式作为刺激来诱导外周组织氧合变化。使用基于非接触时空的近红外光谱（NIRS）设备，在屏气模式（包括20秒屏气）下对受试者进行成像。深色和浅色皮肤之间的氧合血流变化相似，但伤口部位和正常背景组织之间存在差异。因此，可以在糖尿病足溃疡中评估外周血管对氧合需求的反应能力。
