α-叠氮双膦酸盐：合成与核苷酸类似物。
α-Azido bisphosphonates: synthesis and nucleotide analogues.
机构信息
Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, USA.
出版信息
J Org Chem. 2011 Jun 17;76(12):5132-6. doi: 10.1021/jo200045a. Epub 2011 May 25.
Abstract
The first examples of α-azido bisphosphonates (RO)(2)P(O)CXN(3) (1, R = i-Pr, X = Me; 2, R = i-Pr, X = H; 3, R = H, X = Me; 4, R = H, X = H) and corresponding β,γ-CXN(3) dGTP (5-6) and α,β-CXN(3) dATP (7-8) analogues are described. The individual diastereomers of 7 (7a/b) were obtained by HPLC separation of the dADP synthetic precursor (14a/b).
摘要
描述了首例 α-叠氮双膦酸盐 (RO)(2)P(O)CXN(3) (1, R = i-Pr, X = Me; 2, R = i-Pr, X = H; 3, R = H, X = Me; 4, R = H, X = H) 和相应的β,γ-CXN(3) dGTP (5-6) 和 α,β-CXN(3) dATP (7-8) 类似物。通过 HPLC 分离 dADP 合成前体 (14a/b)，得到了 7 (7a/b) 的各个非对映异构体。
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