Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
J Affect Disord. 2011 Sep;133(1-2):204-11. doi: 10.1016/j.jad.2011.03.022. Epub 2011 Apr 3.
Offspring of parents with bipolar disorder are at increased risk for a range of psychopathology, including bipolar disorder. It is not clear if they also have impairments in their psychosocial functioning.
We compared the psychosocial functioning of three groups of children enrolled in the Pittsburgh Bipolar Offspring Study (BIOS): offspring of probands with bipolar disorder (n=388), offspring of probands with other types of psychopathology (n=132), and offspring of healthy probands (n=118). Psychosocial functioning was assessed at study intake using the schedule of the Adolescent Longitudinal Interval Follow-Up Evaluation (A-LIFE), the Child Behavior Check List (CBCL) and the Children's Global Assessment Scale (CGAS).
Offspring of probands with bipolar disorder exhibited impairments in various aspects of psychosocial functioning. On all measures, they had worse functioning in comparison with offspring of healthy probands. Offspring of probands with bipolar disorder generally exhibited more impairment than offspring of probands with nonbipolar psychopathology. After adjusting for proband parent functioning and the child's Axis I psychopathology, functioning of offspring of probands with bipolar disorder was similar to that of offspring of healthy probands.
Data are cross-sectional and therefore do not allow for causal conclusions about the association between parental psychopathology, child psychopathology and offspring psychosocial functioning.
Offspring of parents with bipolar disorder exhibit impairments in psychosocial functioning which appear largely attributable to proband parent functional impairment and the child's own psychopathology. As such, interventions to improve parental functioning, as well as early interventions to treat the child's psychopathology may help reduce the risk for long-term functional impairment in offspring.
父母患有双相障碍的子女患多种精神病理学的风险增加，包括双相障碍。目前尚不清楚他们的社会心理功能是否也存在障碍。
我们比较了匹兹堡双相障碍后代研究（BIOS）中三组儿童的社会心理功能：双相障碍先证者的后代（n=388）、其他类型精神病理学先证者的后代（n=132）和健康先证者的后代（n=118）。在研究开始时，使用青少年纵向间隔随访评估（A-LIFE）、儿童行为检查表（CBCL）和儿童总体评估量表（CGAS）评估社会心理功能。
双相障碍先证者的后代在社会心理功能的各个方面都存在障碍。在所有指标上，他们的功能均比健康先证者的后代差。与非双相精神病理学先证者的后代相比，双相障碍先证者的后代通常表现出更多的障碍。在调整先证者父母的功能和孩子的轴 I 精神病理学后，双相障碍先证者的后代的功能与健康先证者的后代相似。
数据是横断面的，因此不能对父母精神病理学、儿童精神病理学和后代社会心理功能之间的关联得出因果结论。
父母患有双相障碍的子女在社会心理功能方面存在障碍，这些障碍在很大程度上归因于先证者父母的功能障碍和孩子自身的精神病理学。因此，干预措施以改善父母的功能，以及早期干预孩子的精神病理学，可能有助于降低后代长期功能障碍的风险。
