非酒精性脂肪性肝炎（NASH）患者的血浆维生素 E 和类胡萝卜素水平降低。
Plasma levels of vitamin E and carotenoids are decreased in patients with Nonalcoholic Steatohepatitis (NASH).
机构信息
Klinik für Gastroenterologie, Hepatologie und Infektiologie, Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.
出版信息
Eur J Med Res. 2011 Feb 24;16(2):76-8. doi: 10.1186/2047-783x-16-2-76.
OBJECTIVES
Oxidative stress is suggested to play an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH). The present study was aimed to compare plasma levels of antioxidants in patients suffering from NASH and healthy controls.
METHODS
Plasma levels of the antioxidants α-tocopherol, γ-tocopherol, lutein, zeaxanthin, β-cryptoxanthin, lycopene, α-carotene β-carotene were determined in 57 patients with biopsy-proven NASH and 40 healthy controls.
RESULTS
Levels of α-tocopherol (22.4 vs. 26.8 nmol/ ml; p<0.01), lutein (0.19 vs. 0.33 nmol/ml; p<0.0001), zeaxanthin (0.04 vs. 0.08 nmol/ml; p<0.0001), lyco?pene (0.15 vs. 0.42 nmol/ml; p<0.0001), α-carotene (0.03 vs. 0.06 nmol/ml; p<0.005) and β-carotene (0.25 vs. 0.39 nmol/ml; p<0.01) were significantly decreased in NASH patients compared to controls. Age, aminotransferase status (ALT, AST) and BMI were not correlated with the levels of tocopherols or caro?tenoids.
CONCLUSIONS
Given the decreased levels supplementation of lipophilic antioxidants might be a rational treatment option for patients with NASH.
目的
氧化应激被认为在非酒精性脂肪性肝炎（NASH）的发病机制中起重要作用。本研究旨在比较患有 NASH 和健康对照组患者的血浆抗氧化剂水平。
方法
在 57 例经活检证实的 NASH 患者和 40 名健康对照者中测定血浆抗氧化剂α-生育酚、γ-生育酚、叶黄素、玉米黄质、β-隐黄质、番茄红素、α-胡萝卜素和β-胡萝卜素的水平。
结果
与对照组相比，NASH 患者的α-生育酚（22.4 与 26.8 nmol/ml；p<0.01）、叶黄素（0.19 与 0.33 nmol/ml；p<0.0001）、玉米黄质（0.04 与 0.08 nmol/ml；p<0.0001）、番茄红素（0.15 与 0.42 nmol/ml；p<0.0001）、α-胡萝卜素（0.03 与 0.06 nmol/ml；p<0.005）和β-胡萝卜素（0.25 与 0.39 nmol/ml；p<0.01）水平显著降低。年龄、转氨酶状态（ALT、AST）和 BMI 与生育酚或类胡萝卜素水平无关。
结论
鉴于脂溶性抗氧化剂水平降低，补充此类抗氧化剂可能是 NASH 患者的合理治疗选择。
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