Department of Endocrinology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Horm Res Paediatr. 2011;75(5):367-73. doi: 10.1159/000324107. Epub 2011 Apr 5.
Isolated premature pubarche (PP) is commonly caused by premature adrenarche (PA), and links between PA, children born small for gestational age (SGA) and insulin resistance have already been made in some populations.
We assessed anthropometric data, pubertal landmarks and metabolic profile at diagnosis and during the study in 52 girls with the diagnosis of isolated PP from a Brazilian cohort.
The prevalence of obesity (25%), dyslipidemia (63.5%) and born SGA children (21.2%) was greater among PP girls than in the reference population (4, 46.8 and 10%, respectively). There was no increase in the prevalence of insulin resistance and no correlation with birth weight, onset of PP or other pubertal signs. The Z score of heights at PP diagnosis was greater than the Z score of mid-parental height, but achieved final height (n = 16 girls, p = 0.002) was similar to normal population standards and to the predicted final height based on bone age at PP diagnosis (p = 0.08). Thelarche and menarche occurred at normal age, just earlier than expected.
The prevalence of children born SGA, obese and dyslipidemic, but not of hyperinsulinemic children, was high in our cohort of PP girls. Puberty started earlier than usual but within the normal range.
孤立性性早熟（PP）通常由肾上腺早现（PA）引起，一些人群中已经发现 PA 与出生体重小于胎龄（SGA）和胰岛素抵抗之间存在关联。
我们评估了来自巴西队列的 52 名孤立性 PP 女孩在诊断时和研究期间的人体测量数据、青春期标志和代谢特征。
PP 女孩中肥胖症（25%）、血脂异常（63.5%）和出生 SGA 儿童（21.2%）的患病率高于参考人群（分别为 4%、46.8%和 10%）。胰岛素抵抗的患病率没有增加，与出生体重、PP 发病或其他青春期标志无关。PP 诊断时身高 Z 评分大于中亲身高 Z 评分，但最终身高（n=16 名女孩，p=0.002）与正常人群标准和基于 PP 诊断时骨龄预测的最终身高（p=0.08）相似。乳房发育和初潮发生在正常年龄，只是比预期的早。
我们的 PP 女孩队列中，SGA、肥胖和血脂异常儿童的患病率较高，但高胰岛素血症儿童的患病率并不高。青春期开始得比通常早，但在正常范围内。
