Pere A, Perheentupa J, Peter M, Voutilainen R
Children's Hospital, University of Helsinki, Finland.
Eur J Pediatr. 1995 May;154(5):346-52.
In a follow up study of 34 patients with premature adrenarche we examined serum adrenal androgen levels and growth. The majority (28/34) showed an upward bend in the growth curve which, at the mean age of 2.3 years, preceded other signs of adrenarche on average by 3.8 years. Pubertal growth spurt was missing or reduced in 50% of the patients (8/16), however, final height did not differ from that expected from parental heights. Adrenal androgens did not remain elevated at adolescence. The mean age at menarche for all the girls was 0.5 years younger than in the general population.
Our findings imply that premature adrenarche may start earlier than previously recognized. Compared to ordinary growth these children seem to use a greater part of their potential for adult height already at that early age.
在一项对34例肾上腺功能初现过早的患者的随访研究中，我们检测了血清肾上腺雄激素水平和生长情况。大多数患者（28/34）的生长曲线出现上升趋势，在平均2.3岁时，平均比肾上腺功能初现的其他体征提前3.8年。50%的患者（8/16）青春期生长突增缺失或减弱，然而，最终身高与根据父母身高预期的身高并无差异。肾上腺雄激素在青春期并未持续升高。所有女孩的初潮平均年龄比一般人群小0.5岁。
我们的研究结果表明，肾上腺功能初现过早可能比之前认为的开始得更早。与正常生长相比，这些儿童在幼年时似乎就已经将其成年身高潜力的更大一部分用于生长了。
