Sugihara Masako, Oka Rie, Sakurai Masaru, Nakamura Koshi, Moriuchi Tadashi, Miyamoto Susumu, Takeda Yoshiyu, Yagi Kunimasa, Yamagishi Masakazu
Department of Internal Medicine, Hokuriku Central Hospital, Japan.
Intern Med. 2011;50(7):679-85. doi: 10.2169/internalmedicine.50.4292. Epub 2011 Apr 1.
Early studies have indicated that body fat shifts from peripheral stores to central stores with aging. The objective of this study was to investigate age-related changes in abdominal fat distribution of Japanese men and women of the general population over a wide range of body mass indices (BMI).
A total of 2,220 non-diabetic, apparently healthy Japanese adults (1,240 men and 980 women; age range 40-69 years) were included in the study sample. All subjects underwent a CT scan at the level of the umbilicus, and the areas of visceral adipose tissue (AT) and subcutaneous AT were quantified.
When the subjects were stratified by BMI into 18.5-23.0 kg/m(2), 23.0-27.5 kg/m(2), and 27.5 kg/m(2) or higher, visceral AT was positively correlated with age in all of the BMI strata in both genders (p<0.01). In contrast, subcutaneous AT was negatively correlated with age in men with BMIs in excess of 23.0 kg/m(2) (p<0.01) and not at all in women. The mean levels of subcutaneous AT were over 2-fold greater than visceral AT in women aged 60-69 years in any BMI stratum.
In Japanese men and women, visceral AT was increased with age in all BMI strata in both genders, whereas subcutaneous AT was decreased with age in men with BMIs in excess of 23.0 kg/m(2) and not at all in women. Even with these age-related changes in abdominal fat distribution, women retained the subcutaneous-dominant type of fat distribution up to 70 years.
早期研究表明，随着年龄增长，身体脂肪会从外周储存部位转移至中心储存部位。本研究的目的是调查普通人群中日本男性和女性在广泛的体重指数（BMI）范围内腹部脂肪分布的年龄相关变化。
共有2220名非糖尿病、看似健康的日本成年人（1240名男性和980名女性；年龄范围40 - 69岁）纳入研究样本。所有受试者均在脐水平进行CT扫描，并对内脏脂肪组织（AT）和皮下AT的面积进行量化。
当根据BMI将受试者分为18.5 - 23.0 kg/m²、23.0 - 27.5 kg/m²以及27.5 kg/m²及以上三组时，在所有BMI分层中，男女两性的内脏AT均与年龄呈正相关（p<0.01）。相比之下，BMI超过23.0 kg/m²的男性皮下AT与年龄呈负相关（p<0.01），而女性则完全无此相关性。在任何BMI分层中，60 - 69岁女性的皮下AT平均水平比内脏AT高出2倍以上。
在日本男性和女性中，所有BMI分层的男女两性内脏AT均随年龄增加，而BMI超过23.0 kg/m²的男性皮下AT随年龄减少，女性则无此变化。即使腹部脂肪分布存在这些与年龄相关的变化，女性在70岁之前仍保持皮下脂肪占主导的分布类型。
