欧洲血统与老年非裔美国人的静息代谢率。
European ancestry and resting metabolic rate in older African Americans.
机构信息
Department of Aging and Geriatric Research, University of Florida, Institute on Aging, Gainesville, USA.
出版信息
Eur J Clin Nutr. 2011 Jun;65(6):663-7. doi: 10.1038/ejcn.2011.22. Epub 2011 Apr 6.
BACKGROUND/OBJECTIVES: Resting metabolic rate (RMR) contributes 60-80% of total energy expenditure and is consistently lower in populations of African descent compared with populations of European populations. Determination of European ancestry (EA) through single nucleotide polymorphism (SNP) analysis would provide an initial step for identifying genetic associations that contribute to low RMR. We sought to evaluate the association between RMR and EA in African Americans.
SUBJECTS/METHODS: RMR was measured by indirect calorimetry in 141 African American men and women (aged 74.7±3.0 years) enrolled in a substudy of the Health, Aging and Body Composition Study. Ancestry informative markers were used to estimate individual percent EA. Multivariate regression was used to assess the association between RMR and EA after adjustments for soft tissue fat-free mass (STFFM), fat mass, age, study site, physical activity level and sex.
RESULTS
Mean EA was 23.8±16% (range: 0.1-70.7%) and there were no differences by sex. Following adjustments, each percent EA was associated with a 1.6 kcal/day (95% Confidence interval: 0.42, 2.7 kcal/day) higher RMR (P=0.008). This equates to a 160 kcal/day lower RMR in a population of completely African ancestry, with one of completely European ancestry. Additional adjustment for trunk STFFM that partially accounts for high-metabolic rate organs did not affect this association.
CONCLUSIONS
EA in African Americans is strongly associated with higher RMR. The data suggest that population differences in RMR may be due to genetic variants.
背景/目的：静息代谢率（RMR）占总能量消耗的 60-80%，与欧洲人群相比，非裔人群的 RMR 一直较低。通过单核苷酸多态性（SNP）分析确定欧洲血统（EA）将为确定导致低 RMR 的遗传关联提供第一步。我们旨在评估非裔美国人的 RMR 与 EA 之间的关联。
受试者/方法：在健康、衰老和身体成分研究的子研究中，对 141 名非裔美国男性和女性（年龄 74.7±3.0 岁）进行间接热量法测量 RMR。使用遗传信息标记来估计个体的 EA 百分比。多元回归用于评估 RMR 与 EA 之间的关联，调整软组织去脂体重（STFFM）、脂肪量、年龄、研究地点、体力活动水平和性别后。
结果
平均 EA 为 23.8±16%（范围：0.1-70.7%），且性别之间无差异。调整后，EA 每增加 1%，RMR 增加 1.6 kcal/天（95%置信区间：0.42，2.7 kcal/天）（P=0.008）。这相当于在一个完全非洲血统的人群中，RMR 降低 160 kcal/天，而在一个完全欧洲血统的人群中，RMR 降低 160 kcal/天。进一步调整部分解释高代谢率器官的躯干 STFFM 并未影响这种关联。
结论
非裔美国人的 EA 与较高的 RMR 密切相关。数据表明，RMR 的人群差异可能是由于遗传变异所致。
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