抗生素捕获转录起始中间体：是解链还是弯曲，哪个为先？
Antibiotics trapping transcription initiation intermediates: To melt or to bend, what's first?
作者信息
Brodolin Konstantin
机构信息
Université Montpellier 1; Université Montpellier 2; CNRS UMR 5236; Centre d'études d'agents Pathogènes et Biotechnologies pour la Santé; Montpellier, France.
出版信息
Transcription. 2011 Mar;2(2):60-65. doi: 10.4161/trns.2.2.14366.
Abstract
Promoter DNA melting, culminating in the loading of the single-stranded DNA template into the RNA polymerase active site, is a key step in transcription initiation. Recently, the first transcription inhibitors found to block distinct steps of promoter melting were characterized. Here, the impact of these studies is discussed with respect to the current models of transcription initiation.
摘要
启动子DNA解链，最终将单链DNA模板装载到RNA聚合酶活性位点，是转录起始的关键步骤。最近，发现了第一批能够阻断启动子解链不同步骤的转录抑制剂，并对其进行了表征。在此，将结合当前的转录起始模型讨论这些研究的影响。
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