Department of Food Science and Technology, Bahauddin Zakariya University, Multan, Pakistan.
Biol Trace Elem Res. 2011 Dec;144(1-3):894-903. doi: 10.1007/s12011-011-9050-9. Epub 2011 Apr 6.
Changes in plasma glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), triiodothyronine (T3), and thyroxin (T4) of male rats, following 8 weeks of administration of different concentrations of elemental iron (EI), sodium iron ethylenediaminetetraacetate (NaFeEDTA), zinc sulfate (ZnSO(4)), and zinc oxide (ZnO) in whole wheat flour were investigated. Liver enzymes and thyroid hormones were determined using colorimetric methods and enzyme immune assay, respectively. Ingestion of fortified diets by the male rats did not show a marked effect on GOT and GPT, the exception being NaFeEDTA fed alone and EI with ZnO-fortified diets indicating a significant (p < 0.05) decrease in GOT levels in rats. Similarly, only NaFeEDTA significantly (p < 0.05) increased thyroxin, while EI, ZnSO(4), and ZnO either alone or in any combination did not alter thyroid secretions. Changes in GOT, GPT, T3, and T4 levels, as a result of ingesting iron and zinc-fortified diets by rats, ranged in the safe limits.
研究了雄性大鼠连续 8 周摄入不同浓度的元素铁（EI）、乙二胺四乙酸铁钠（NaFeEDTA）、硫酸锌（ZnSO4）和氧化锌（ZnO）后，其血浆谷氨酸草酰乙酸转氨酶（GOT）、谷氨酸丙酮酸转氨酶（GPT）、三碘甲状腺原氨酸（T3）和甲状腺素（T4）的变化。采用比色法和酶免疫分析法分别测定肝酶和甲状腺激素。雄性大鼠摄入强化饮食并未对 GOT 和 GPT 产生明显影响，除单独摄入 NaFeEDTA 和含有 ZnO 的 EI 饮食组大鼠 GOT 水平显著降低（p<0.05）外。同样，只有 NaFeEDTA 显著（p<0.05）增加了甲状腺素，而 EI、ZnSO4 和 ZnO 单独或联合使用均未改变甲状腺激素的分泌。大鼠摄入铁和锌强化饮食导致 GOT、GPT、T3 和 T4 水平的变化均在安全范围内。
