Siegel M M, Siegel S E, Isaacs H, Weitzman J J, Hanson B A, Higgins G R, Shore N A
Med Pediatr Oncol. 1978;4(4):297-304. doi: 10.1002/mpo.2950040404.
Four children presenting with unresectable hepatoblastomas and one with metastatic disease are reported. Following initial biopsy all were treated with chemotherapy which included Adriamycin. Three of the four children showed a significant reduction in tumor size, and in two, delayed resection of the primary lesion was possible. Chemotherapy including Adriamycin represents effective initial cytoreductive therapy for childhood hepatoblastoma, thereby reducing the morbidity and mortality associated with the extensive hepatic resection usually required for an untreated lesion.
报告了4例患有不可切除性肝母细胞瘤的儿童和1例患有转移性疾病的儿童。在初次活检后，所有患儿均接受了包括阿霉素在内的化疗。4名儿童中有3名肿瘤大小显著缩小，其中2名患儿得以延迟切除原发性病灶。包括阿霉素在内的化疗是儿童肝母细胞瘤有效的初始细胞减灭疗法，从而降低了与未经治疗的病灶通常所需的广泛肝切除相关的发病率和死亡率。
