Weinblatt M E, Siegel S E, Siegel M M, Stanley P, Weitzman J J
Cancer. 1982 Sep 15;50(6):1061-4. doi: 10.1002/1097-0142(19820915)50:6<1061::aid-cncr2820500607>3.0.co;2-q.
Eight children presenting with unresectable primary hepatic malignancies were treated with chemotherapy in an attempt to decrease the size of the tumor. Adriamycin was used in all drug regimens, usually in combination with cyclophosphamide, vincristine, and 5-fluorouracil. Seven children exhibited a pronounced, clinical response with marked reduction in the size of the primary tumor as well as any pulmonary metastases present. Four children were able to have complete, uncomplicated surgical excision of residual disease, and three are alive and well off therapy. One patient with hepatocellular carcinoma had compete disappearance of all disease with chemotherapy alone. An approach utilizing preoperative chemotherapy for extensive hepatic malignancies may permit eventual resection of initially inoperable lesions, with long-term survival for these highly lethal malignancies.
八名患有无法切除的原发性肝脏恶性肿瘤的儿童接受了化疗，试图缩小肿瘤大小。所有化疗方案均使用阿霉素，通常与环磷酰胺、长春新碱和5-氟尿嘧啶联合使用。七名儿童出现明显的临床反应，原发性肿瘤以及存在的任何肺转移灶的大小均显著减小。四名儿童能够完整、顺利地手术切除残留病灶，三名儿童在停止治疗后仍存活且状况良好。一名肝细胞癌患者仅通过化疗就使所有病灶完全消失。对于广泛的肝脏恶性肿瘤，采用术前化疗的方法可能会使最初无法手术切除的病灶最终得以切除，从而使这些高度致命的恶性肿瘤患者获得长期生存。
