Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nat Rev Immunol. 2011 Feb;11(2):81. doi: 10.1038/nri2922.
Immunometabolism is an emerging field of investigation at the interface between the historically distinct disciplines of immunology and metabolism. Accelerating interest in this area is being fuelled by the obesity epidemic and the relatively recent realization that obesity affects the immune system and promotes inflammation, and that obesity-induced inflammation potentially promotes a variety of chronic conditions and diseases. The multilevel interactions between the metabolic and immune systems suggest pathogenic mechanisms that may underlie many of the downstream complications of obesity and offer substantial therapeutic promise.
免疫代谢是免疫学和代谢学这两个历史上截然不同的学科之间的一个新兴研究领域。肥胖症的流行以及最近才意识到肥胖会影响免疫系统并促进炎症，而且肥胖引起的炎症可能会促进多种慢性疾病，这些都加速了人们对该领域的兴趣。代谢和免疫系统之间的多层次相互作用表明了可能是肥胖的许多下游并发症的潜在发病机制，并提供了很大的治疗前景。
