电化学疗法治疗癌症患者：希腊的首次临床试验。

Electrochemotherapy in cancer patients: first clinical trial in Greece.

机构信息

First Department of Radiation Oncology, St. Savvas Anticancer Hospital of Athens, 171 Alexandras Ave., 11522, Athens, Greece.

出版信息

In Vivo. 2011 Mar-Apr;25(2):265-74.

PMID:21471545

Abstract

Electrochemotherapy is currently undergoing intensive investigation in the field of local control of cancer. In Greece, five medical centers have co-operated to perform ECT for the efficient management of growing, recurrent or newly emerging cutaneous and subcutaneous tumor nodules. ECT was applied alone or in combination with external beam radiation therapy, brachytherapy and surgery in 52 cancer patients, using bleomycin according to standard protocols. The treatment response for various tumors was 63.83% complete, 31.91% partial, and 95.74% overall of the treated nodules. Patients exerted neither systemic nor local side-effects. The results of ECT performance in Greece provided evidence that this new treatment strategy is safe and permits the effective control of tumors of various origins and histological types.

摘要

电化学疗法目前正在癌症的局部控制领域进行深入研究。在希腊，五个医疗中心合作开展 ECT，以有效治疗不断生长、复发或新出现的皮肤和皮下肿瘤结节。在 52 名癌症患者中，根据标准方案使用博来霉素单独或联合外部束放射治疗、近距离放射治疗和手术应用 ECT。各种肿瘤的治疗反应为完全缓解 63.83%、部分缓解 31.91%，总的处理结节为 95.74%。患者未出现全身或局部副作用。希腊 ECT 治疗结果提供了证据，证明这种新的治疗策略是安全的，并能有效控制各种来源和组织学类型的肿瘤。