2型糖尿病患者昼夜皮质醇节律变平缓。
Flattened circadian cortisol rhythm in type 2 diabetes.
作者信息
Lederbogen F, Hummel J, Fademrecht C, Krumm B, Kühner C, Deuschle M, Ladwig K-H, Meisinger C, Wichmann H-E, Lutz H, Breivogel B
机构信息
Central Institute of Mental Health, Mannheim, Germany.
出版信息
Exp Clin Endocrinol Diabetes. 2011 Oct;119(9):573-5. doi: 10.1055/s-0031-1275288. Epub 2011 Apr 6.
INTRODUCTION
While altered cortisol concentrations have been observed in subjects with type 2 diabetes their circadian cortisol profile is unknown.
PATIENTS AND METHODS
Using a cross-sectional design, we studied 63 ambulatory individuals with type 2 diabetes and 916 non-diabetic control subjects of the Cooperative Research in the Region of Augsburg (KORA)-F3 study. Circadian cortisol profiles were derived from saliva cortisol concentrations, determined on a regular weekday upon wake-up (F0), as well as ½ h (F½), 8 (F8) and 14 h (F14) after wake-up.
RESULTS
Diabetic subjects exhibited a flattened circadian cortisol profile (rm-ANOVA: F[3,654]=3.41, p=0.02), with lower morning and higher afternoon and evening cortisol concentrations.
CONCLUSION
We observed a flattened circadian cortisol rhythm in subjects with type 2 diabetes, providing evidence for a specific HPA system dysfunction.
引言
虽然在2型糖尿病患者中观察到皮质醇浓度改变，但其昼夜皮质醇谱尚不清楚。
患者与方法
采用横断面设计，我们研究了奥格斯堡地区合作研究（KORA）-F3研究中的63名非卧床2型糖尿病患者和916名非糖尿病对照受试者。昼夜皮质醇谱由唾液皮质醇浓度得出，在工作日常规起床时（F0）以及起床后半小时（F½）、8小时（F8）和14小时（F14）测定。
结果
糖尿病患者呈现出扁平的昼夜皮质醇谱（重复测量方差分析：F[3,654]=3.41，p=0.02），早晨皮质醇浓度较低，下午和晚上皮质醇浓度较高。
结论
我们观察到2型糖尿病患者的昼夜皮质醇节律扁平，为特定的下丘脑-垂体-肾上腺（HPA）系统功能障碍提供了证据。
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